Low dose naltrexone
[UPDATED JULY 2022]
The idea behind using low dose naltrexone is to stimulate the production of endogenous (the body’s own) opiates. These have disease modifying effects in a wide range of conditions and there is now good evidence for this. For further information see Wikipedia:Low dose naltrexone and LDN Research Trust
Naltrexone on its own has very little effect on the body. Typically, it is used to reverse the effects of poisoning by opiates such as morphine, and is the perfect antidote to, for example, morphine or a morphine-like substance which may be used for darting and tranquillising wild animals. They will wake up within a few minutes if injected with naltrexone. The usual dose of naltrexone to treat opiate poisoning is 50mgs. The daily dose of naltrexone for our purposes is 4mgs.
Naltrexone is available in the UK on prescription, either from your GP or from a private practitioner. It comes in several forms - as capsule, liquid or transdermal cream.
Obtaining a prescription
Dicksons Chemists in Glasgow run a telephone consultation and prescription service for LDN. See Dicksons telephone LDN consultation and prescription service and Dicksons LDN Urgent prescriber consultation
Recent Study and Case Reports
A recent study  "Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment" which can be seen here concluded that:
These data support the hypothesis that LDN may have potential as a treatment for ME/CFS by characterising the underlying regulatory mechanisms of LDN treatment involving TRPM3 and opioid receptors in NK cells.
A Case Report Study  - "Low-dose naltrexone as a treatment for chronic fatigue syndrome" concluded that:
This series of three case reports compiled by people with long-term ill-health due to chronic fatigue syndrome shows the range of responses they observed when taking LDN, from life changing to a reduction in some symptoms only
There is a Facebook Group with lots of knowledgeable members and further useful links here - Facebook Group - "LDN LOW DOSE NALTREXONE FOR ME/CFS MYALGIC ENCEPHALOMYELITIS & FIBROMYALGIA"
- Wikipedia:Low dose naltrexone
- LDN Research Trust - a very informative website where you will find a down-loadable info pack for GPs.
- Dicksons telephone LDN consultation and prescription service
- Dicksons LDN Urgent prescriber consultation
- Facebook Group - "LDN LOW DOSE NALTREXONE FOR ME/CFS MYALGIC ENCEPHALOMYELITIS & FIBROMYALGIA"
- "Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment"
- "Low-dose naltrexone as a treatment for chronic fatigue syndrome"
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