GI Effects Fundamentals

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Test Details for Ordering
Test GI Effects Fundamentals
Laboratory Genova Diagnostics
Price £262.50 (plus £77.50 for Parasitology)
Sample required stool
To order this test, please, go to Ordering Tests.

Please, make sure you have read When not to use this website to ascertain whether having this test is an appropriate and safe course of action for you.

[UPDATED JULY 2022]
This new test replaces the old tests:

  • Comprehensive Digestive Stool Analysis (CDSA)
  • Comprehensive Digestive Stool Analysis with parasitology (CDSA + P)

Please note - postage

  • UK clients - please use Royal Mail or the courier to return samples - YOU PAY FOR THIS YOURSELVES ie complete payment on the courier form if you wish to use the courier.
  • Overseas clients - my Office will charge you a courier fee to ship the test kit to you and this will be billed along with the test kit, but you must organise and pay the courier return fee ie fill in payment on courier form.

All kits come with shipping instructions for returning the samples.

Here are the relevant Genova documents explaining the procedure:

NOTE

The GI Effects Fundamentals is replacing the old Comprehensive Digestive Stool Analysis. If you want to add in a Parasitology check, please let us know and we can request this as an add on.

DESCRIPTION

What is the GI Effects Fundamentals?

The GI Effects Fundamentals stool profile offers valuable insight into digestive function, intestinal inflammation, and the intestinal microbiome. Optional add-on tests allow the clinician to choose pertinent markers for each patient, including parasitology and others.

The core biomarkers from the GI Effects Fundamentals Profile are reported using the DIG framework, providing key clinical information for three main gastrointestinal functional areas (markers denoted with * are not available in NY):

Digestion/Absorption:

  • Pancreatic Elastase-1 is a marker of exocrine pancreatic function.
  • Products of Protein Breakdown are markers of undigested protein reaching the colon.
  • Fecal Fat is a marker of fat breakdown and absorption.

Inflammation/Immunology:

  • Calprotectin is a marker of neutrophil-driven inflammation. Produced in abundance at sites of inflammation, this biomarker has been proven clinically useful in differentiating between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).1,2
  • Eosinophil Protein X is a marker of eosinophil-driven inflammation and allergic response.
  • Fecal Occult Blood detects hidden blood.

Gut Microbiome:

  • Metabolic indicators demonstrate specific and vital metabolic functions performed by the microbiota. These include:
    • Beneficial Short–Chain Fatty Acids (SCFA), including n–Butyrate, are fermentation products produced by bacterial action on fiber and resistant starch. N-butyrate is the primary fuel source for colonocytes.
    • Beta-glucuronidase* is an enzyme produced by bacteria that relates to the metabolism and detoxification of certain substances.
  • Bacteria and mycology cultures demonstrate the presence of specific beneficial and pathogenic organisms.
  • Bacteria and mycology sensitivities are provided for pathogenic or potentially pathogenic organisms that have been cultured. The report includes effective prescriptive and natural agents.

Additional Biomarkers Available:

  • Parasitology
    • Includes microscopic fecal specimen examination for ova and parasites (O&P), the gold standard of diagnosis for many parasites.
    • 6 Polymerase chain reaction (PCR) targets* detect common protozoan parasites including Blastocystis spp., Cryptosporidium parvum/hominis, *Cyclospora cayetanensis, Dientamoeba fragilis, Entamoeba histolytica, and Giardia.
  • Secretory IgA*
  • Campylobacter
  • Clostridium difficile
  • Escherichia coli
  • Helicobacter pylori*
  • Macroscopic Exam for Worms
  • KOH Preparation for Yeast
  • Zonulin Family Peptide

When should GI Effects Fundamentals be considered?

The GI Effects Fundamentals Profile can reveal important information about the root cause of many common gastrointestinal symptoms such as gas, bloating, indigestion, abdominal pain, diarrhea, and constipation.

What advantage does the GI Effects Fundamentals offer compared to other diagnostics?

A structured fecal biomarker panel offers the advantage of assessing multiple functional areas that may be contributing to symptoms. For example, diarrhea can originate from multiple causes including pancreatic exocrine insufficiency, inflammation, food allergies, or the presence of a pathogenic or potentially pathogenic organism.3,4

GI Effects profiles utilize the best technical platforms to assess gut health, including Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) technology for cultivable species identification, as well as stool-based biomarkers for gastrointestinal diagnostics.

What can clinicians and patients expect from stool testing?

The GI Effects Fundamentals Profile biomarkers provide comprehensive information for the development of strategic interventions. Symptoms often improve as identified functional imbalances and inadequacies become normalized through targeted dietary, lifestyle, and supplementation therapeutics.

References

1.Menees SB, et. al. A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBS. Am J Gastroenterol. 2015 Mar;110(3):444-54.
2.Dabritz J, Musci J, Foell D. Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome. World J Gastroenterol. 2014 Jan;20(2):363-375.
3.Parsons K, et. al. Novel testing enhances irritable bowel syndrome medical management: the IMMINENT study. Glob Adv Health Med. 2014 May;3(3):25-32.
4.Goepp J, et. al. Frequency of abnormal fecal biomarkers in irritable bowel syndrome. Glob Adv Health Med. 2014 May;3(3):9-15.

SAMPLE

This test is performed on three stool samples.
See the Genova 3 day stool collection instruction leaflet here - Genova 3 day stool collection instruction leaflet

INSTRUCTIONS

Important message about "interfering substances":

On the Genova 3 day stool collection instruction leaflet you are advised by the Laboratory

  • 2- 4 weeks before - Discontinue antibiotics, antiparasitics,antifungals, probiotic supplements (acidophilus, etc.).
  • 14 days before - If your clinician ordered the H. pylori test, discontinue proton pump inhibitors (PPIs), and bismuth.
  • 2 days before - Discontinue aspirin and other NSAIDs (i.e. ibuprofen), rectal suppositories, enemas, activated charcoal, bismuth, betaine HCL, digestive enzymes, antacids, laxatives, mineral oil, castor oil, and/or bentonite clay


My advice is that as long as I have a full list of what you are taking at the time of the test, I will be able to interpret your results correctly.

Nutritional supplements, digestive aids

Many of my patients take a range of nutritional supplements, digestive enzymes, betaine hydrochloride or bile salts. Please, continue taking your usual supplements, probiotics and digestive aids as normal around the time of the test.

Antibiotics or antifungals

  • If you are taking a short course of antibiotics for an acute infection, or a short course of antifungals, wait for 2 weeks before collecting a stool sample for the test.
  • If you are on long term antibiotics or antifungals, continue them as normal – the test result will allow me to assess their effect.

In all cases, please let me know clearly what you are taking!

Doing the test

  • Collect the samples by following the instructions enclosed with the test kit.
  • Make sure that your name, date of birth and date sample taken are correctly entered on the sample tube.
  • Make sure all the necessary details are correct on the laboratory request form.


Please, note that there is an interpretation fee for my letter to your GP. See Ordering Tests for more details.